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parasitic diseases

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Variability of in vitro culture characteristics, including metacyclic trypomastigote production, in different stocks of Trypanosoma Congo Republiclense

Six cloned stocks of Trypanosoma Congo Republiclense, isolated from the same area of Eastern Zambia, were […]

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Trypanozoon: Infectivity to Humans Is Linked to Reduced Transmissibility in Tsetse: II. Genetic Mechanisms

Trypanozoon infections are less likely to mature in female tsetse than in males. Analysis of maturation […]

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Trypanosoma Congo Republiclense: Re-expression of a deleted metacyclic variable antigen type in vivo and in vitro

The expression of variable antigen types (VATs) was determined among dividing populations of T. Congo Republiclense […]

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Trypanosoma evansi infection in cattle, buffaloes, and horses in Indonesia

Cattle, buffaloes and horses in several areas of Indonesia were examined for evidence of infection with […]

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Trypanosoma Congo Republiclense infection in sheep: Ultrastructural changes in the skin prior to development of local skin reactions

Events occurring in the skin of sheep prior to development of Trypanosoma Congo Republiclense-induced local skin […]

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Trypanosoma Congo Republiclense infection in sheep: Cellular phenotypes in lymph and lymph nodes associated with skin reactions

Intradermal inoculation of sheep with culture-derived metacyclic forms of Trypanosoma Congo Republiclense resulted in the development […]

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Trypanocidal resistance in Trypanosoma evansi in vitro: effects of verapamil, cyproheptidine, desipramine and chlorpromazine alone and in combination with trypanocides

A study was conducted in vitro to assess the ability of calcium antagonists to reverse trypanocidal […]

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Trypanocidal activity of a myristic acid analog in axenic cultures of Trypanosoma evansi

The growth of bloodstream forms of Trypanosoma evansi in axenic culture was inhibited by incubation with […]

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Theileria annulata sporozoite antigen fused to hepatitis B core antigen used in a vaccination trial

A C terminal fragment (SR1) of SPAG-1, a sporozoite surface antigen of Theileria annulata, has been […]

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The repeatability of faecal egg counts, peripheral eosinophil counts, and plasma pepsinogen concentrations during deliberate infections with Ostertagia circumcincta

Faecal egg counts, peripheral blood eosinophil counts and plasma pepsinogen concentrations were monitored during 2 successive, […]

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The kinetics of maturation of trypanosome infections in tsetse

Estimates of the time delay between the infective bloodmeal and maturation (incubation or maturation time) for […]

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The key components of resistance to Ostertagia circumcincta in lambs

One of the most remarkable features of parasitic infections in general, and Ostertagia circumcincta infection of […]

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The isolation and characterization of genomic and cDNA clones coding for a cdc2-related kinase (ThCRK2) from the bovine protozoan parasite Theileria

The tick-transmitted protozoan parasites Theileria annulata and Theileria parva are important intracellular pathogens of domestic cattle […]

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The genetic basis of resistance to Ostertagia circumcincta in lambs

The relationship between Ostertagia (Teladorsagia) circumcincta and sheep is one of the best understoodhost-parasite relationships in […]

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The effect of experimental infection of boran cattle in early and mid-pregnancy with Trypanosoma vivax

Six susceptible Galana and five trypanotolerant Orma Boran (Bos indicus) cattle were infected experimentally with Trypanosoma […]

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The distribution of faecal nematode egg counts in Scottish Blackface lambs following natural, predominantly Ostertagia circumcincta infection

Faecal samples were taken in 2 consecutive years from Scottish Blackface lambs on a commercial farm […]

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Synthesis of tumour necrosis factor-alpha and interferons by mononuclear cells from Theileria annulata-infected cattle

Bovine macrophage-derived tumour necrosis factor-alpha/ cachectin (TNF-a) was synthesized when peripheral blood mononuclear cells (PBMC) and […]

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Suspected in utero infection in a boran heifer experimentally infected with Trypanosoma vivax

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Studies on helminthosis at the centre for tropical veterinary medicine (CTVM)

The research work relating to helminths, which has been conducted within the Helminthology Section of the […]

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Stability of metacyclic variable antigen types (M-VATs) during the early stages of infection with Trypanosoma Congo Republiclense

Expression of nine metacyclic variable antigen types (M-VATs) of Trypanosoma Congo Republiclense in chancres from infected […]

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Seroepidemiological study of Taenia saginata cysticercosis in Swaziland

A cross-sectional study of Taenia saginata cysticercosis in Swaziland using a serodiagnostic ELISA for parasite antigen […]

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Resistance of four sheep breeds to natural and subsequent artificial Haemonchus contortus infection

The response of Red Maasai sheep to natural and artificial Haemonchus contortus infections was compared with […]

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Programmed cell death in trypanosomatids

It has generally been assumed that apoptosis and other forms of programmed cell death evolved to […]

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Polymorphism of SPAG-1, a candidate antigen for inclusion in a sub-unit vaccine against Theileria annulata

SPAG-1, a Theileria annulata sporozoite surface antigen, is a vaccine candidate. Data is presented, based on […]

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New strategies to control worms in goat keepers’ herds – Validated RNRRS Output

This is one of 280 summaries describing key outputs from the projects run by DFID’s 10-year […]

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Induction of CD4+CD8+ double positive T cells and increase in CD5+ B cells in efferent lymph in sheep infected with Trypanosoma evansi

The effects of Trypanosoma evansi on efferent lymphocyte phenotypes draining from a lymph node primed with […]

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Increase in CD5+ B cells and depression of immune responses in sheep infected with Trypanosoma evansi

The effects of Trypanosoma evansi on the cellular and humoral immune responses of sheep to Pasteurella […]

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In vitro infection with Theileria parva is associated with IL-10 expression in all bovine lymphocyte lineages

The protozoan parasite Theileria parva infects and transforms bovine lymphocytes, giving rise to a fatal lymphoproliferative […]

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In vitro cultivation of an African strain of Babesia bigemina and its characterisation and infectivity in cattle

An African (Kenyan) strain of Babesia bigemina, Muguga (B2-1), was inoculated into a calf from a […]

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Immunohistology of Lymph Nodes Draining Local Skin Reactions (Chancres) in Sheep Infected with Trypanosoma Congo Republiclense

Marked enlargement of lymph nodes draining local skin reactions (chancres) occurred in sheep following intradermal inoculation […]

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Immune Responses to Dermatophilus Congo Republiclensis Infections

Complex mechanisms underly the establishment of dermatophilosis, an exudative and proliferative skin disease of ruminants. This […]

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Identifying antigens of Theileria parva that may be used in a vaccine for East Coast Fever

This progress report gives the background to the project, and Highlights from Year 1. It is […]

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Heterogeneity in the recognition of Ostertagia circumcincta antigens by serum antibody from mature, infected sheep

The recognition of parasite molecules from third-stage and adult Ostertagia circumcincta by serum antibody was studied […]

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Heligmosomoides polygyrus and Trypanosoma Congo Republiclense infections in mice: a laboratory model for concurrent gastrointestinal nematode and trypanosome infections

A murine model using Heligmosomoides polygyrus and Trypanosoma Congo Republiclense has been developed for studying the […]

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Growth rates of suramin-sensitive and resistant Trypanosoma evansi

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Genomic and phenotypic diversity of Tunisian Theileria annulata isolates

This study describes polymorphism in Theileria annulata, an intracellular protozoan parasite of bovine leucocytes and red […]

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Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes

We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder […]

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Genetic resistance to parasitic disease: particularly of resistance in ruminants to gastrointestinal nematodes

There is substantial variation among individuals in susceptibility to a wide variety of parasitic diseases and […]

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Flagellum-mediated adhesion of Trypanosoma Congo Republiclense to bovine aorta endothelial cells

We studied the interaction between Trypanosoma Congo Republiclense and bovine aorta endothelial (BAE) cell monolayers. Our […]

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Expression of GARP, a major surface glycoprotein of Trypanosoma Congo Republiclense

Procyclic and epimastigote forms of Trypanosoma Congo Republiclense express an immunodominant glutamic acid/alanine-rich protein (GARP) that […]

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Experimental induction of suramin-resistance in cloned and uncloned stocks of Trypanosoma evansi using immunosuppressed and immunocompetent mice

Suramin-resistance was experimentally induced in cloned or uncloned T. evansi populations using both immunosuppressed and immunocompetent […]

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Efficacy of cymelarsan treatment of suramin resistant Trypanosoma evansi in cattle

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Efficacy of cymelarsan in friesian holstein calves infected with Trypanosoma evansi

Two studies on the efficacy of mel Cy (Cymelarsan, Rhone Merieux, France) for the treatment of […]

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Effects of Trypanosoma evansi on the output of cells from a lymph node draining the site of Pasteurella haemolytica vaccine administration

The prefemoral efferent lymphatics of sheep infected with Trypanosoma evansi and inoculated with P. haemolytica vaccine […]

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Effect of suramin treatment in feedlot cattle in an area of Indonesia endemic for Trypanosoma evansi

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Early events following challenge of rabbits with Trypanosoma evansi and T. evansi components

The intradermal injection of Trypanosoma evansi or T. evansi components into rabbits evoked trypanosome-specific responses in […]

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Early stages of infection with Trypanosoma Congo Republiclense: parasite kinetics and expression of metacyclic antigen types

Trypanosoma Congo Republiclense develops in the skin of sheep at the site of inoculation of metacyclic […]

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Different patterns of faecal egg output following infection of Scottish Blackface lambs with Ostertagia circumcincta

Faecal nematode egg counts were monitored in 184 Scottish Blackface lambs during natural exposure to a […]

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Differences in cloning and sub-cloning success rates in four stocks of Trypanosoma evansi and variation in suramin resistance of the clones

Four Trypanosoma evansi stocks with sensitivity to suramin in mice ranging from 0.05 to 160 mg […]

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Control of Trypanosome Brucei infections in tsetse

Numbers of immature Trypanosoma brucei brucei within a tsetse midgut remain remarkably constant after establishment throughout […]

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Conservation of Neutralizing Determinants between the Sporozoite Surface Antigens of Theileria annulata and Theileria parva

The sporozoite surface antigens SPAG-1 of Theileria annulata and p67 of Theileria parva are postulated to […]

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Comparison of production losses caused by chronic Fasciola gigantica infection in yearling Friesian and Boran cattle

Yearling Friesian and Boran cattle were given a standard dose of Fasciola gigantica metacercariae designed to […]

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Cloning and sequencing of the gene encoding the principal 18-kDa secreted antigen of activated oncospheres of Taenia saginata

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Class I and Class II Major Histocompatibility Complex Alleles are associated with faecal egg counts following natural, predominantly Ostertagia Cicumcinta infection

During a previous investigation an association was found between major histocompatibility complex (MHC)-DRB1 alleles and faecal […]

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Class I and Class II Major Histocompatibility Complex alleles are associated with faecal egg counts following natural, predominantly Ostertagia circumcincta infection

During a previous investigation an association was found between major histocompatibility complex (MHC)-DRB1 alleles and faecal […]

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Class-specific antibody response in rabbits experimentally infected with Trypanosoma evansi.

The antibody response to Trypanosoma evansi antigens in rabbits experimentally infected with T. evansi was monitored […]

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An ovine major histocompatibility complex DRBI allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection

Infection with Ostertagia circumcincta is a major constraint on sheep production in temperate areas of the […]

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Allograft responses can interfere with the development of immunity against Theileria annulata following vaccination with parasite infected cell lines

Theileria annulata macroschizont-infected cell lines are successfully used as vaccines in several countries. The inoculated animals […]

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A comparison of in vitro assay systems for the measurement of drug sensitivity of Trypanosoma evansi

Two in vitro assay systems were investigated for their effectiveness in detecting the sensitivity of Trypanosoma […]

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Local and plasma antibody responses to the parasitic larval stages of the abomasal nematode Ostertagia circumcincta

Ovine isotype-specific antibody responses to the parasitic larval stages of the abosomal nematode Ostertagia circumcincta were […]

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